Cefotaxime injection may also be used before surgery, and during and after a cesarean section, in order to prevent the patient from getting an infection. Cefotaxime injection is in a class of medications called cephalosporin antibiotics. It works by killing bacteria. Antibiotics such as cefotaxime injection will not work for colds, flu, or ...
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Objective: To prepare and validate the chemical structure of the cefotaxime dimer and cefotaxime trimer impurities available from pharmaceutical industry. Methods: A polymer stock solution of cefotaxime sodium was obtained using a concentrated solution degradation method. The cefotaxime dimer and trimer impurities were separated and …
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ChEBI: Cefotaxime is a cephalosporin compound having acetoxymethyl and [2- (2-amino-1,3-thiazol-4-yl)-2- (methoxyimino)acetyl]amino side groups. It has a role as a drug allergen and an antibacterial drug. It is a member of 1,3-thiazoles, an oxime O-ether and a cephalosporin. It is a conjugate acid of a cefotaxime (1-).
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Cefotaxime sodium is a broad-spectrum antibiotic used to treat various bacterial infections. This product is a USP reference standard, which means it meets the highest quality and purity criteria for use in official USP-NF tests and assays. Learn more about its biochem/physiol actions, certificate of analysis and traceability to primary standards.
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Summary of Use during Lactation . Limited information indicates that cefotaxime produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately …
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Among the spectroscopic techniques, 1 H NMR and 13 C NMR elucidated the key functional groups at various chemical shifts while ESI-MS pointed out the molecular weight of cefotaxime sodium in various generations. Similarly, FTIR, DSC, and AFM investigations detailed that the generations are devoid of incompatibilities, structural deformities and ...
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Objective: To prepare and validate the chemical structure of the cefotaxime dimer and cefotaxime trimer impurities available from pharmaceutical industry.Methods: A polymer stock solution of cefotaxime sodium was obtained using a concentrated solution degradation method. The cefotaxime dimer and trimer impurities were separated and …
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sodium picosulfate/magnesium oxide/anhydrous citric acid; ticarcillin; voclosporin; warfarin; Cefotaxime has minor interactions with the following drugs: aminohippurate sodium; chloramphenicol; choline magnesium trisalicylate; rose hips ; sulfasalazine; willow bark ; This information does not contain all possible interactions or adverse effects.
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Buy Cefotaxime sodium Ph Eur reference standard for identification, purity tests or assays of pharmaceutical products according to EP monographs. VN EN. ... Cefotaxime acid. View Price and Availability. Sigma-Aldrich. C7912. Cefotaxime sodium salt. View Price and Availability. USP. 1097953.
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Cefotaxime for injection is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7- [2- (2-amino-4-thiazolyl ... Following IM administration of a single 500 mg or 1 g dose of Cefotaxime to normal volunteers, mean peak serum concentrations of 11.7 and 20.5 mcg/mL respectively were ...
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Cefotaxime using 1, 2-napthaquinone-4-sulfonic acid sodium in bulk and pharmaceutical dosage form CH. Aswani Kumar, T. Anil Kumar, B. M. Gurupadayya*, S. Navya Sloka and M. B.
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Generic name: cefotaxime sodium. Dosage form: injection, powder, for solution. Drug class: Third generation cephalosporins. J Code (medical billing code): J0698 (Per 1 g, injection) Medically reviewed by …
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Cefotaxime. Sharon S. Castle, in xPharm: The Comprehensive Pharmacology Reference, 2007 Therapeutics. Cefotaxime is active against gram-positive organisms and a wide range of gram-negative organisms, excluding pseudomonas. Staphylococcal coverage lessens in this third-generation group. Cefotaxime is used for the treatment of meningitis, lower …
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This chapter provides an overview of cefotaxime. It discusses the nomenclature, formula, molecular weight, and appearance, color, odor, and taste of cefotaxime. Various physical properties—solubility, moisture content, pH range, optical rotation, and spectral properties—are discussed. Cefotaxime is a semisynthetic …
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in which C is the concentration,in mg per mL,of USP Cefotaxime Sodium RS in the Standard preparation, P is the designated content,in µg per mg,of cefotaxime (C 16 H 17 N 5 O 7 S 2)in USP Cefotaxime Sodium RS, W is the weight,in mg,of Cefotaxime Sodium taken to prepare the Assay preparation,and r U and r S are the cefotaxime peak area …
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Cefotaxime. Desacetyl-cefotaxime accounts for 15% to 45% of the peak and 45% to 70% of the trough concentrations of total cefotaxime [417–419]. ... cephalosporanic acid; cefatoxamine; cefotaxime sodium; claforan; hr 756; ru 24756; zariviz; 7 [2 (2 amino 4 thiazolyl) 2 methoxyiminoacetamido]cephalosporanic acid; 7 [2 (2 aminothiazol 4 yl) 2 ...
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Sterile CLAFORAN (cefotaxime sodium) is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7-[2-(2 …
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The pH is adjusted with hydrochloric acid and may be adjusted with sodium hydroxide. The plastic container is fabricated from a specially designed multilayer plastic (PL 2040). Solutions are in ... Cefotaxime sodium is highly stable in vitro to four of the five major classes of 5-lactamases described by Richmond et al.1, including type IIIa ...
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1 g cefotaxime (free acid equivalent) in vials in packages of 10 (NDC 0039-0018-10), packages of 25 ... Cefotaxime sodium overdosage has occurred in patients. Most cases have shown no overt toxicity. The most frequent reactions were elevations of BUN and creatinine. There is a risk of reversible encephalopathy in cases of administration of high ...
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2-methoxyiminoacetamido]cephalosporanic acid sodium salt1. Cefotaxime is a broad-spectrum third-generation cephalosporin antibiotic with a wide spectrum of activity. It has particular potency against Gram-negative bacteria such as Enterobacteriaceae, Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, and Neisseria species.
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Chlorogenic acid (CGA) is an active component of Yinhua Pinggan Granule, which has antioxidant and anti-inflammatory effects. We chose the CGA to explore its effects on PANoptosis in cultured macrophages infected with CSR-EC. In this study, we explored the protective impact of CGA on macrophage cell damage generated by CSR …
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The values of percentage inhibition efficiency (% IE) and corrosion rate (CR) obtained from weight loss method at different concentrations of cefotaxime sodium in 1 N HCl at 35 °C are summarized in Table 1.The variation of inhibition efficiency with increase in inhibitor concentrations is shown in Fig. 2.It was observed that cefotaxime sodium …
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Cefotaxime sodium is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefotaxime has activity in the presence of some of beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. ... 1 g cefotaxime (free acid equivalent) vials in packages of 25 (NDC 0143-9931-25) 2 g ...
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Cefotaxime sodium–tazobactam sodium injection (6:1) was well-tolerated at doses of 0.47 to 4.68 g. ... (0.05% acetic acid and 5 mM ammonium acetate). Mass spectrometry was performed using the negative electrospray ionization mode. Analytes were extracted from aliquots of 50.0 μl plasma or urine samples by protein precipitation …
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Antibiotics are commonly used in clinical practice to treat bacterial infections. Due to the abuse of antibiotics, the emergence of drug-resistant strains, such as cefotaxime sodium-resistant Escherichia coli (CSR-EC), has aggravated the treatment of diseases caused by bacterial infections in the clinic. Therefore, discovering new drug …
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Cefotaxime is a prescription medication used to treat the symptoms of Gonococcal Urethritis / Cervicitis, Gonorrhea, Rectal, Infections Caused by Susceptible Organisms, …
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cefotaxime decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Use Caution/Monitor. Coadministration with antibiotics …
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CLAFORAN contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. Solutions of CLAFORAN range from very pale yellow to light amber depending on the concentration and the diluent used. The pH of the injectable solutions usually ranges from 5.0 to 7.5. The CAS Registry Number is 6.
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Comparison: cefotaxime sodium CRS. B. It gives reaction (a) of sodium (2.3.1). TESTS Solution S. Dissolve 2.5 g incarbon dioxide-free water R and dilute to 25.0 ml with the same solvent. Appearance ofsolution. SolutionS isclear (2.2.1). Add 1 ml of glacial acetic acid R to 10 ml of solution S. The solution, examined immediately, is clear.
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ChEBI: Cefotaxime is a cephalosporin compound having acetoxymethyl and [2- (2-amino-1,3-thiazol-4-yl)-2- (methoxyimino)acetyl]amino side groups. It has a role as a drug allergen and an antibacterial drug. It is a member of 1,3-thiazoles, an oxime O-ether and a cephalosporin. It is a conjugate acid of a cefotaxime (1-).
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This study was conducted after dehydrogenating cefotaxime sodium using 0.75 ml of sodium nitrite and 0.75 ml of hydrochloric acid. The solutions were left on ice for 5 min at 0–5 °C, after which increasing volumes of urea solution (0.25–2.0) were added) ml at a concentration of 1 % to get rid of excess nitrogen gas, then 1 ml of 0.5 % ...
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